Charalabos Pothoulakis Selected Research

Pseudomembranous Enterocolitis (Pseudomembranous Colitis)

10/2011	The insect peptide coprisin prevents Clostridium difficile-mediated acute inflammation and mucosal damage through selective antimicrobial activity.
7/2008	gp96 is a human colonocyte plasma membrane binding protein for Clostridium difficile toxin A.
7/2006	Epithelial cell I kappa B-kinase beta has an important protective role in Clostridium difficile toxin A-induced mucosal injury.
6/2004	Corticotropin-releasing hormone (CRH) requirement in Clostridium difficile toxin A-mediated intestinal inflammation.
8/2003	Clostridium difficile toxin B is an inflammatory enterotoxin in human intestine.

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Charalabos Pothoulakis Research Topics

Disease

71	Inflammation (Inflammations) 01/2021 - 08/2002
53	Colitis 01/2021 - 03/2003
20	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2021 - 01/2006
15	Neoplasms (Cancer) 01/2021 - 03/2002
11	Diarrhea 10/2011 - 03/2003
9	Ulcerative Colitis 08/2019 - 12/2003
9	Enteritis 02/2016 - 03/2002
7	Colonic Neoplasms (Colon Cancer) 01/2021 - 03/2002
7	Obesity 04/2015 - 11/2007
6	Irritable Bowel Syndrome (Syndrome, Irritable Bowel) 01/2021 - 02/2012
6	Infections 01/2019 - 06/2005
6	Crohn Disease (Crohn's Disease) 10/2015 - 01/2006
5	Body Weight (Weight, Body) 12/2018 - 03/2008
5	Edema (Dropsy) 10/2016 - 08/2002
5	Hyperalgesia 01/2015 - 07/2005
5	Pseudomembranous Enterocolitis (Pseudomembranous Colitis) 10/2011 - 08/2003
4	Carcinogenesis 10/2019 - 08/2008
3	Clostridium Infections 01/2020 - 09/2013
3	Gastrointestinal Diseases (Functional Gastrointestinal Disorders) 11/2017 - 03/2012
3	Fibrosis (Cirrhosis) 01/2015 - 11/2010
3	Necrosis 09/2013 - 09/2007
3	Ileitis 03/2013 - 06/2007
3	Weight Gain 12/2011 - 03/2008
3	Weight Loss (Weight Reduction) 06/2010 - 01/2006
2	Mitochondrial Diseases (Mitochondrial Disease) 01/2021 - 04/2002
2	Intestinal Diseases (Diseases, Intestinal) 01/2021 - 11/2006
2	Colorectal Neoplasms (Colorectal Cancer) 01/2021 - 10/2015
2	Hypoxia (Hypoxemia) 01/2019 - 12/2014
2	Pediatric ulcerative colitis 12/2018 - 05/2015
2	Neoplasm Metastasis (Metastasis) 01/2018 - 11/2015
2	Vomiting 10/2016 - 01/2014
2	Insulin Resistance 01/2014 - 12/2011

Drug/Important Bio-Agent (IBA)

25	CytokinesIBA 12/2018 - 10/2004
20	Substance PIBA 12/2019 - 12/2002
17	Clostridium difficile tcdA proteinIBA 08/2014 - 03/2002
15	NeuropeptidesIBA 12/2019 - 12/2002
14	sodium sulfate (sodium bisulfate)FDA LinkGeneric 01/2021 - 08/2008
14	Dextrans (Dextran)FDA Link 01/2021 - 08/2008
13	NeurotensinIBA 01/2016 - 06/2003
12	Messenger RNA (mRNA)IBA 01/2021 - 04/2006
11	Neurokinin-1 Receptors (Neurokinin 1 Receptor)IBA 06/2011 - 12/2002
10	MicroRNAs (MicroRNA)IBA 01/2021 - 11/2011
9	Dextran SulfateIBA 01/2021 - 12/2003
8	Peptides (Polypeptides)IBA 11/2016 - 11/2006
7	Corticotropin-Releasing HormoneIBA 10/2019 - 08/2002
7	Sulfonic AcidsIBA 01/2018 - 01/2006
7	NF-kappa B (NF-kB)IBA 09/2007 - 04/2002
6	InterleukinsIBA 09/2014 - 04/2002
6	Anti-Bacterial Agents (Antibiotics)IBA 08/2014 - 03/2003
6	Enterotoxins (Enterotoxin)IBA 09/2013 - 03/2002
5	Interleukin-10 (Interleukin 10)IBA 10/2020 - 01/2006
5	Proteins (Proteins, Gene)FDA Link 11/2018 - 12/2003
5	Interleukin-6 (Interleukin 6)IBA 01/2014 - 01/2006
5	LeptinIBA 12/2011 - 03/2003
5	ErbB Receptors (EGF Receptor)IBA 02/2011 - 10/2004
4	AzoxymethaneIBA 01/2021 - 04/2012
4	Corticotropin-Releasing Hormone Receptors (Corticotropin Releasing-Hormone Receptor)IBA 01/2021 - 08/2002
4	Biomarkers (Surrogate Marker)IBA 01/2021 - 02/2012
4	Phenobarbital (Luminal)FDA Link 10/2020 - 07/2006
4	ChemokinesIBA 04/2015 - 09/2006
4	AcidsIBA 01/2015 - 05/2009
4	CathelicidinsIBA 01/2015 - 11/2011
4	Toll-Like Receptors (Toll-Like Receptor)IBA 09/2014 - 07/2006
4	Peroxidase (Myeloperoxidase)IBA 09/2013 - 06/2007
4	Interleukin-8 (Interleukin 8)IBA 02/2011 - 12/2002
4	FlagellinIBA 11/2010 - 09/2005
4	6- diphenylmethyl- 5- (5- isopropyl- 2- methoxybenzylamino)- 1- azabicyclo(2.2.2)octane- 3- carboxylic acidIBA 11/2010 - 04/2006
3	Hormones (Hormone)IBA 12/2019 - 06/2010
3	Long Noncoding RNAIBA 08/2019 - 01/2016
3	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2019 - 12/2014
3	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2018 - 08/2002
3	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 01/2018 - 09/2006
3	LigandsIBA 11/2015 - 03/2002
3	Neurotensin Receptors (Neurotensin Receptor)IBA 07/2015 - 05/2009
3	CollagenIBA 01/2015 - 11/2010
3	Insulin (Novolin)FDA Link 01/2014 - 06/2011
3	Glucose (Dextrose)FDA LinkGeneric 01/2014 - 06/2011
3	Drinking WaterIBA 01/2014 - 12/2003
3	Vancomycin FDA LinkGeneric 10/2011 - 10/2004
3	Mitogen-Activated Protein KinasesIBA 08/2006 - 12/2002
2	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 01/2021 - 06/2005
2	PAR-2 ReceptorIBA 01/2021 - 06/2007
2	Macrophage Inflammatory Proteins (Macrophage Inflammatory Protein 1)IBA 01/2020 - 08/2008
2	ExotoxinsIBA 01/2019 - 08/2003
2	TensinsIBA 12/2018 - 09/2014
2	Phosphoric Monoester Hydrolases (Phosphatases)IBA 12/2018 - 09/2014
2	RNA (Ribonucleic Acid)IBA 11/2018 - 11/2011
2	FidaxomicinIBA 01/2018 - 08/2014
2	AdipokinesIBA 01/2018 - 11/2007
2	LactoferrinIBA 01/2018 - 01/2013
2	TachykininsIBA 09/2015 - 01/2014
2	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 07/2014 - 06/2007
2	Neurokinin-1 Receptor AntagonistsIBA 01/2014 - 12/2003
2	Serotonin (5 Hydroxytryptamine)IBA 11/2013 - 11/2009
2	Antimicrobial PeptidesIBA 09/2013 - 01/2013
2	AntibodiesIBA 10/2012 - 08/2008
2	Metronidazole (Metric)FDA LinkGeneric 10/2011 - 10/2004
2	GlucocorticoidsIBA 12/2010 - 07/2008

Therapy/Procedure

3	Therapeutics 03/2012 - 03/2008
2	Injections 01/2018 - 01/2016